Reduction of sugar lactones to hemiacetals with lithium triethylborohydride.
نویسندگان
چکیده
Reduction of ribono-1,4-lactones and gulono-1,4-lactone as well as ribono-1,5-lactone and glucono-1,5-lactones with LTBH (1.2 equiv.) in CH2Cl2 at 0 °C for 30 min provided the corresponding pentose or hexose hemiacetals in high yields. Commonly used in carbohydrate chemistry protecting groups such as trityl, benzyl, silyl, acetals and to some extent acyls are compatible with this reduction.
منابع مشابه
Organocatalytic enantioselective Michael addition of cyclic hemiacetals to nitroolefins: a facile access to chiral substituted 5- and 6-membered cyclic ethers.
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ورودعنوان ژورنال:
- Carbohydrate research
دوره 432 شماره
صفحات -
تاریخ انتشار 2016